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Past Scholars

SCHOLAR PROFILES

Read the profiles of recent scholars to learn about their exciting research:

2006 Scholar - Jayanta Debnath

2005 Scholar - Karl Deisseroth

2005 Scholar - Sharon Maynard

2005 Scholar - Loren Walensky

 

 

2007 Scholar Awards

UNIVERSITY OF CALIFORNIA - SAN FRANCISCO
San Francisco, California
For the research of Feroz Papa, MD, PhD, entitled "Endoplastic Reticulum Stress and Type II Diabetes."

Dr. Papa’s lab at the University of California San Francisco studies a newly recognized group of diseases caused by protein misfolding in a cellular compartment called the endoplasmic reticulum (ER). Healthy cells fold proteins properly in their ERs. When proteins misfold in the ER and then clump together in this compartment, cells become damaged and can eventually die. Type 2 diabetes, as well as some neurodegenerative diseases like Parkinson’s, Alzheimer’s, Huntington’s and MS, might be caused in part by “ER stress” caused by misfolded proteins. Dr. Papa’s lab studies how cells normally reverse the ER stress state, to figure out how to make cells more resistant to the dangerous effects of ER stress by using drugs to augment the cells’ natural defenses. His lab has devised a new way to control the activity of a key component that reverses ER stress called Ire1alpha, using a combination of chemistry and genetics—“chemical-genetics”.  For his Culpeper research, Dr. Papa will utilize these new “chem-gen” tools to build a mouse model of ER stress-induced diabetes, in order to test and expand our current understanding of human type 2 diabetes, and thereby promote drug discovery for this and other ER stress-related diseases.

HARVARD MEDICAL SCHOOL/MASSACHUSETTS GENERAL HOSPITAL
Cambridge, Massachusetts
For the research of Bradley Bernstein, MD, PhD entitled "Epigenetic Regulation of Development and Disease by the MLL Oncoprotein."


Dr. Bernstein’s laboratory studies gene regulation – how genes are turned ‘on’ or ‘off’ in a given cell or tissue. Carefully orchestrated gene regulation is essential for normal cel processes, but when regulation breaks down it can lead to cancer. Dr. Berstein’s Culpepe project will focus on a protein called MLL which appears to play a significant role in the development of the human cancer leukemia.  MLL regulates genes by changing the structure of the genetic DNA. Cutting edge genomic technologies will be used to study the influence of MLL on DNA structure and gene expression. Normal tissues and cancerous cells will be examined with the eventual goal of understanding how MLL disrupts genes to cause disease.

COLUMBIA UNIVERSITY
New York, New York
For the research of Stephen Tsang, MD, PhD, entitled "Can Neuronal Function be Recovered After Degeneration has Started?"

There are many diseases of vision. Age-related macular degeneration (AMD) and retinitis pigmentosa (RP) are the most common diseases of photoreceptors, the cells that “see” light and convert light into electrical impulses sent to the brain. These photoreceptors are crucial to vision, and these diseases lead to blindness.  Over twelve million Americans are affected with photoreceptor degeneration, far exceeding the number with Alzheimer’s and Parkinson’s diseases. Inherited forms of photoreceptor degeneration affect about one in 2,000 people. Currently there is no cure. Dr. Tsang’s Culpeper research project involves manipulation of genes in photoreceptor degeneration in mice. This disease in mice parallels similar conditions in humans. The Culpeper Scholarship supports his efforts to find better managements for photoreceptor degeneration in AMD, RP and related photoreceptor diseases.

 

2006 Scholar Awards

UNIVERSITY OF CALIFORNIA - SAN FRANCISCO
San Francisco, California

For the research of Jayanta Debnath, MD, entitled "The Role and Regulation of Autophagy in Epithelial Cell Homeostatis and Cancer."

HARVARD MEDICAL SCHOOL/MASSACHUSETTS GENERAL HOSPITAL
Cambridge, Massachusetts

For the research of Vamsi Mootha, MD, entitled "Functional Genomic Dissection of Human Mitochondrial Disorders."

VANDERBILT UNIVERSITY
Nashville, Tennessee

For the research of Kevin Niswender, MD, PhD, entitled "Therapeutic Discovery for Obesity."

2005 Scholar Awards

DANA-FARBER CANCER INSTITUTE
Boston, Massachusetts

For the research of Loren D. Walensky, MD, PhD, entitled "Activating Apoptosis in Cancer Using Hydrocarbon-Stapled Helices."

GEORGE WASHINGTON UNIVERSITY
Washington D.C

For the research of Sharon Maynard, MD, entitled "Treatment of Preeclampsia by SFltl Knock-Down Using RNA Interference."

STANFORD UNIVERSITY
Stanford, California

For the research of Karl Deisseroth, MD, PhD, entitled "Mechanism and Significance of Adult Excitation-Neurogenesis Coupling."

  

2006 Scholar Awards

HARVARD UNIVERSITY

Cambridge, Massachusetts

For the research of Cammie Lesser, MD, PhD, entitled "Characterization of Pathogenic Mycobacterial Proteins in Yeast." 

 
STANFORD UNIVERSITY
Stanford, California
For the research of Ajay Chawla, MD, PhD, entitled "Metabolic Control of Aging by Peroxisome Proliferator Activated Receptor."

UNIVERSITY OF TEXAS, SOUTHWESTERN
Dallas, Texas

For the research of Christine Kim Garcia, MD, PhD, entitled "The Genetics of Emphysema."

Prior to 2004

ALBERT EINSTEIN COLLEGE OF MEDICINE
Bronx, New York

For the research of Michael P. Lisanti, MD, PhD, entitled "Caveolin: A Target for Drug Discovery."

BAYLOR COLLEGE OF MEDICINE
Houston, Texas
For the research of Mark Hughes, MD, PhD, entitled "Hormone Receptor Mutations in Patients with D-Resistant Rickets."

For the research of David B. Roth, MD, PhD, entitled "Molecular Analysis of the V(D)J Recombination Mechanism and its Contributions to Immunodeficiency and Cancer."

COLUMBIA UNIVERSITY
New York, New York
For the research of Asa Ableiovich, MD, PhD, entitled "Genetics of Parkinson’s Disease."

For the research of Jeremy Luban, MD, entitled "Cyclophilin Function in Signal Transduction and Development."

For the research of C. Daniel Salzman, MD, PhD, entitled "Concerning the Neural Mechanisms that Underlie Emotional Behavior."

CORNELL UNIVERSITY
Ithaca, New York

For the research of Jacqueline F. Bromberg, MD, PhD, entitled "Oncogenesis."

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or the research of Jay M. Edelberg, MD, PhD, entitled "The Role of Systemically-Derived Endothelial Cells in the Senescent Cardiac Microvascular Communication."

DANA-FARBER CANCER INSTITUTE
Boston, Massachusetts

For the research of Lynda Chin, MD, PhD, entitled "Genetic Analysis of Tumor Maintenance in the Mouse."

DUKE UNIVERSITY
Durham, North Carolina
For the research of Michael Seldin, MD, PhD, entitled "Isolation of the Autoimmune Gene gld."

EMORY UNIVERSITY
Atlanta, Georgia

For the research of Kerry James Ressler, MD, PhD, entitled "The Molecular Neurobiology of Fear in Mammals."

HARVARD UNIVERSITY
Cambridge, Massachusetts

For the research of David Matthew Altshuler, MD, PhD, entitled "Genomic Approaches to the Genetics of Diabetes and Response to Hypoglycemic Medications."

For the research of Andrew D. Luster, MD, PhD, entitled "The Role of Eotaxin in Asthma and Allergic Diseases."

For the research of Evan D. Rosen, MD, PhD, entitled "Comparative Genomic Approaches to Understanding the Transcriptional Basis of Adipogenesis."

JOHNS HOPKINS UNIVERSITY
Baltimore, Maryland
For the research of Guo-li Ming, MD, PhD, entitled "Repair and Regeneration of Axons Following Injury or Damage to the Central Nervous System."

For the research of Mark S. Schlissel, MD, PhD, entitled "NF-kB and the Activation of Immunoglobulin k Gene Transcription and Rearrangement."

MICHIGAN STATE UNIVERSITY
East Lansing, Michigan

For the research of Gretchen L. Birbeck, MD, PhD, entitled "Complex and Recurrent Febrile Seizures as a Risk Factor for Epilepsy in Zambia."

NEW YORK UNIVERSITY
New York, New York

For the research of Mary Ann Thompson Arildsen, MD, entitled "NGF-Medicated Neuronal Differentiation."

For the research of Michael B. Whitlow, MD, PhD, entitled "The Protection of Cells from Complement Attack."

STANFORD UNIVERSITY
Stanford, California
For the research of Russ B. Altman, MD, PhD, entitled "New Computer Methods for Understanding Molecular Structure."

For the research of Anthony E. Oro, MD, PhD, entitled "The Stromal Regulation of Basal Cell Carcinoma Formation."

TUFTS UNIVERSITY
Medford, Massachusetts
For the research of Stephanie Lee, MD, PhD, entitled "Molecular Basis of Rat Thyrotropin- Releasing Hormone Expression in Neuroendocrine Cells."

UNIVERSITY OF CALIFORNIA, LOS ANGELES
Los Angeles, California

For the research of Benhur Lee, MD, PhD, entitled "HIV Entry and Pathogenesis."

UNIVERSITY OF CALIFORNIA, SAN DIEGO
San Diego, California
For the research of Steffan N. Ho, MD, PhD, entitled "Transcriptional Regulatory Mechanisms Controlling T Cell Differentiation."

For the research of Fred Levine, MD, PhD, entitled "Molecular Genetics."

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
San Francisco, California

For the research of David S. Bredt, MD, PhD, entitled "Excitotoxicity Mediated by the Nitric Oxide Synthase NMDA Receptor Complex."

For the research of Karen Hsiao, MD, PhD, entitled "Genetics of Human Prion Disease."

For the research of Steven L. McIntire, MD, PhD, entitled "Neuronal Vesicular Amino Acid Transport."

For the research of Keith Mostov, MD, PhD, entitled "Biological Function of Polarized Epithelial Cells."

For the research of Edward Murphy, MD, MPH, entitled "Molecular Epidemiology of HTLV-I."

UNIVERSITY OF CHICAGO
Chicago, Illinois
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or the research of Elizabeth M. McNally, MD, PhD, entitled "Genetic Defect in Myopathy."

UNIVERSITY OF IOWA
Iowa City, Iowa

For the research of C. Michael Knudson, MD, PhD, entitled "Regulation of Apoptosis in Germ Cell Development, Spermatogenesis and Infertility."

UNIVERSITY OF NEW MEXICO
Albuquerque, New Mexico
For the research of Clifford R. Lyons, MD, PhD, entitled "Mechanisms of Host Defense Against Mycobacterium Tuberculosis."

UNIVERSITY OF PENNSYLVANIA
Philadelphia, Pennsylvania

For the research of  Lewis A. Chodosh, MD, PhD, entitled "The Role of BRCA1 in Differentiation Pathways."

UNIVERSITY OF PITTSBURGH
Pittsburgh, Pennsylvania

For the research of Charleen T. Chu, MD, PhD, entitled "Oxidative Stress and Neurotrophic Signaling in Parkinsons Disease.

UNIVERSITY OF TEXAS
Austin, Texas

For the research of Sandra Lee Hofmann, MD, PhD, entitled "Functional Analysis of an SR Protein by Gene Disruption."

UNIVERSITY OF TEXAS MEDICAL BRANCH, GALVESTON
Galveston, Texas

For the research of Joseph M. Vinetz, MD, entitled "Novel Approaches Towards Preventing Malaria Transmission: Molecular and Structural Characterizations of Malaria Parasite Chitinases."

UNIVERSITY OF TEXAS, SOUTHWESTERN
Dallas, Texas

For the research of Jonathan M. Graff, MD, PhD, entitled "The Endogenous Role of the Smads in Vertebrate Development."

For the research of William H. Landschulz, MD, PhD, entitled "Genetic Analysis of Papillary Thyroid Carcinoma."

For the research of John McPhaul, MD, entitled "Cloning and Characterization of the Human Androgen Receptor."

UNIVERSITY OF UTAH
Salt Lake City, Utah

For the research of Dean Y. Li, MD, PhD, entitled "Cloning and Characterizing the Elastin Receptor."

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or the research of Louis J. Ptacek, MD, entitled "Molecular Characterization of Spinocerebellar Degeneration with Peripheral Neuropathy."

VANDERBILT UNIVERSITY
Nashville, Tennessee

For the research of Christopher Ferris, MD, PhD, entitled "The Molecular Basis for the Control of Cellular Iron Levels by Heme Oxygenase."

For the research of Katherine Murray, MD, entitled "Metabolic Regulation of Cardiac Sodium Channel."

WASHINGTON UNIVERSITY
St. Louis, Missouri

For the research of Thomas J. Baranski, MD, PhD, entitled "The Roles of Receptor Structure in G Protein Signaling."

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or the research of Daniel E. Goldberg, MD, PhD, entitled "Studies of Function and Biogenesis of the Unique Hemoglobin- Degrading Organelle of the Malaria Parasite Plasmodium Falciparum."

For the research of Glen Hortin, MD, PhD, entitled "Regulation of the Complement System of Immune Defense."

For the research of Robinna G. Lorenz, MD, PhD, entitled "Molecular and Immunologic Investigation of Intestinal M Cells."

For the research of Dwight A. Towler, MD, PhD, entitled "Molecular Genetics of Osteoblast-Specific Gene Expression."

For the research of Russell Van Gelder, MD, PhD, entitled "Understanding Non-Visual Photoreception at the Basic Science Level."

YALE UNIVERSITY
New Haven, Connecticut

For the research of Peter M. Glazer, MD, PhD, entitled "Molecular Analysis of Mutagenesis in Transgenic Mice."

For the research of Peter J. Hotez, MD, PhD, entitled "Molecular Basis of Hookworm Infectivity and Development and Molecular Parasitology."

 

        

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